How do you sequence ADT relative to the start of RT?

Topics: Radiation Oncology • Genitourinary Cancers

Given the publication by Malone, et al (JCO, 2019), how do you sequence ADT relative to the start of RT? https://ascopubs.org/doi/full/10.1200/JCO.19.01904

Answer from: Radiation Oncologist at Community Practice

Happy New Year to the MedNet! This is a great question that should remind us to question everything. This is an important question that the prostate community I have felt since I was in training has over simplified for decades. First: Our current nomenclature has problems. Most residents and...

Comments

Radiation Oncologist at UC San Diego
Great summary of the data—thank you.

Radiation Oncologist at Millennium Oncology
Could not agree more with this. Pleasant to see su...

Radiation Oncologist at Sidney Kimmel Medical College of Thomas Jefferson University
Well explained. Separating Onco-lore from data.

Radiation Oncologist at UCLA | VA Greater Los Angeles Healthcare System
Great summary. Yet, you left one piece of gristle ...

Radiation Oncologist at Penn Medicine
I do believe that RTOG 0534 started ADT 2 months b...

Answer from: Radiation Oncologist at Academic Institution

Yes, this was an interesting study by Malone et al., which I enjoyed reading. Given the lack of significant advantage to either approach on the study, we continue to typically give 2 months of neoadjuvant ADT. As opposed to the 3DCRT approach on the study, we use VMAT with fairly tight margin...

Comments

Radiation Oncologist at Mount Sinai Medical Center Miami
I thought survival curves in short term Adt studie...

Radiation Oncologist at UC San Diego
I do believe ADT has an effect on occult metastase...

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