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How do you sequence everolimus/endocrine therapy versus fam-trastuzumab deruxtecan after progression on CDK4/6i in metastatic ER+ HER2 low breast cancer?

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After progression on CDK4/6i + ET, how would you sequence everolimus vs T-DXd in HR+/HER2-low metastatic breast cancer?

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1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Ohio State University
Answered on

Since the DESTINY-Breast04 trial required patients to be endocrine therapy resistant and have received 1-2 prior lines of systemic chemotherapy for metastatic disease, I would consider Enhertu only after patients progressed on everolimus and endocrine therapy.

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