What do you think about using prednisone in the first trimester of pregnancy?

The risk of cleft lip/palate with prednisone use during pregnancy is minimal to inconsistent (especially if only a short course). However, long-term use of steroids is associated with an increased risk of gestational diabetes, preeclampsia, fetal growth restriction, and preterm birth.

If prednisone is required for a severe allergic reaction or other acute medical need, it is reasonable to use. If prednisone is an option and not required, it may be best to avoid it due to risks of fetal growth restriction or cleft palate, as you indicated. It is important to weigh risks/benefits w...