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Outside of a clinical trial, how do you approach upfront therapy for a PDGFRA D842V-mutant GIST?
Would your recommendations change in the neoadjuvant versus adjuvant or metastatic setting?
Answer from: Medical Oncologist at Academic Institution
These are usually indolent surgical tumors (until they are not) that belong in the care of a sarcoma center and not in the community. There are two trials of agents that are being tested for D842V mutations at this time (NCT02508532 and NCT02847429).
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