What agent do you typically start with for treatment of patients with anti-HMGCoA myopathy?
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IVIg is a great treatment for anti-HMGCoA antibody necrotizing myopathy. However, traditional treatments like methotrexate, azathioprine, as well as rituximab can be tried. We published a paper on IVIG results on refractory HMGCR and SRP positive patients with excellent results.
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The longitudinal case-series published by Dr. @Dr. First Last and his colleagues provided notable quantitative support for useful role of IVIG in immune-mediated necrotizing myositis (IMNM), including the subtypes typically associated with statin-exposures. These data are also echoed by other author...
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IVIG.
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