How do you treat idiopathic hypersomnia inadequately responding to modafinil?   

I would try a traditional stimulant first, and if they have side effects, then switch to low-sodium oxybate.

I agree with @Dr. Attarian. I usually start my patients on modafinil or armodafinil. If those do not work, I will try solriamfetol. I will supplement with as needed amphetamines as well. I do not often go straight to sodium oxybate/low-sodium oxybate, as you need the right patient for this medicatio...

Although I agree with modafinil or armodafinil as a first-line, amphetamines are problematic both in the mood disorders associated with idiopathic hypersomnolence and in college students. Soriamfetol is intriguing, but since IH is an off-label indication, insurers routinely deny it. Overall, sodium ...

In reviewing the AASM practice guidelines 2021 (1), clarithromycin also has RCT evidence to support it, but must be used cautiously in those with comorbid heart disease, and being wary of the development of antibiotic resistance. Flumazenil also has interesting retrospective data to support it (2) [...