How do you treat locally advanced, operable, Siewert 3 GE junction adenocarcinomas?

This remains an area of controversy, but perhaps not as controversial as Siewert type II tumors. Siewert type III tumors are staged as gastric cancers in the AJCC 8^th edition. In addition, they are more histologically similar to gastric cancer and have patterns of nodal spread like gastric cancer as...

Bryan -

No one else is answering, so I'll give your question a go. If I recall, the Siewart-Stein classification looks at distance from the GE-junction with a 3 being pretty much firmly within the stomach. GE Junction can be treated with MAGIC chemotherapy and surgery or neoadjuvant chemoradiation a...

Siewert type III lesions - subcardial carcinoma with the tumor epicenter between 2 cm and 5 cm below the esophagogastric junction, which infiltrates the esophagogastric junction and lower esophagus from below - are considered gastric cancers. Surgical treatment follows general oncology principles: r...