How do you treat muscle-invasive and metastatic sarcomatoid bladder cancer?
Is there a role for neoadjuvant cisplatin-based chemotherapy?
Do patients with sarcomatoid histology respond to checkpoint inhibitors?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Washington School of Medicine
Answered on
This is a very challenging disease with poor prognosis and low response rate to therapy. If it's predominant or pure sarcomatoid, we are opening a neoadjuvant clinical trial with dose dense MVAC plus pembrolizumab before surgery. If there is no trial, I would do upfront radical cystectomy and PLND f...
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