How do you treat patients with T-cell ALL/T-cell lymphoblastic lymphoma who have pre-existing CKD with a CrCl of 30 mL/min or less?
Many of the agents in either BFM protocols or hyper-CVAD (e.g., methotrexate, cytarabine, 6-mercaptopurine) are renally cleared. How do you deliver the chemotherapy to ensure enough dose intensity but not significant cytopenias/toxicity?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Washington
Answered on · Updated on
In our experience, it requires very close coordination with our clinical pharmacists to ensure proper dose adjustments are made. By doing this, you will hopefully deliver comparable dose intensity without increased toxicity. This assumes you achieve the same level of drug exposure for the agents tha...
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