How do you treat SNUC?

There’s no standard treatment.

Suitable for gross total resection: surgery and postop RT and concomitant chemo.
Not suitable for GTR: chemo RT or induction chemo and reevaluate for surgery and postop RT chemo.

A recent Chinese meta-analysis of 17 studies and about 250 patients showed best results with concurrent chemoRT with a 42% 5-year OS. Induction chemo was of potential benefit in patients who could/wanted to have surgery as an insufficient response to IC was "salvaged" by surgery. In many who don't w...

We most often treat per MDACC induction chemo followed by a definitive CRT retrospective paper. Often these are locally advanced and of course, distant recurrence risk is high. In the few situations where the tumor has no intracranial or orbital extension and is deemed T1/T2 or small T3, we do defin...

IC is controversial for many HN sites. However, for SNUC, one of the benefits (theoretically) is the cytoreduction allows for minimizing radiation to the brain and optics which is one of the major challenges of this disease.

While the approach hasn't changed much, small studies also suggest a spectr...

Because of its aggressive biologic behavior, with a propensity to early invasion (40% to 50%) of vital structures, in addition to its high risk of distant metastasis (20% to 30%), sinonasal undifferentiated carcinoma poses a unique therapeutic challenge. Most published studies report the outcomes of...