How do you treat TBI-associated aggression?

Propranolol has the best evidence, but you can also consider Depakote (since there is an increased risk of seizure as well) or an atypical antipsychotic.

• Fleminger et al., PMID 17054165
• Williamson et al., PMID 31289093
• Khalili et al., PMID 32002583

Aggression with TBI is often associated with impulsivity and seizure disorder.

Depakote offers a safe choice for the impulsive anger and seizure disorders.

Propanolol is helpful to cut down the sympathetic tone, and thus calming patients.

SGAs are good for PRN use and add-on if the full dose of Depa...