How do you treat unresectable pancreatic adenocarcinoma invading into the duodenum?
Would you consider "neoadjuvant" RT to 45-50.4 Gy followed by a resimulation and a boost to a "definitive" dose of 54+ Gy depending upon disease response?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Memorial Sloan-Kettering Cancer Center
Answered on · Updated on
No, 54Gy did not improve survival in the LAP-07 trial, so it is definitively not a definitive dose.
I would give 75Gy in 25 fx (100Gy BED) with capectabine. We have published how we do this in multiple papers, but essentially a 5mm duodenal PRV is carved out of the PTV75 so that there is a gradient...
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