Topics:
Dermatology • Dermatopathology
How do you utilize PRAME for melanocytic biopsies?
- Do you use it for excisions to determine if margins are clear?
- Do you use it for all melanocytic biopsies?
- How do you balance using PRAME with the fact that some studies show that PRAME does not stain some melanomas?
Answer from: at Academic Institution
PRAME is useful as one piece of information to help me decide if I have enough criteria for melanoma in situ. Like most IHC stains it is just a piece of the puzzle to me. In my experience, positivity of MIS is about 7-8/10, so I do not require PRAME positive to diagnose MIS. But positive PRAME helps...
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