How do you wean off of primidone in patients with essential tremors?

If a patient has been on primidone for less than one month, it can be simply discontinued in most cases. Slower withdrawal may be necessary in patients with seizures, patients on multiple other medications, or with other abnormal metabolism.

For patients needing a slower taper, generally lowering the dose by 25-50% every 1-2 weeks works well. Primidone can be discontinued once the patient reaches 25 mg a day for one week.

Keep in mind that some patients may be more sensitive to the effects of w...