How does a mildly elevated CBG (cortisol binding globulin) level affect the interpretation of the 1mg overnight dexamethasone suppression test results?
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In your clinical practice, under which circumstances would you consider avoiding or being cautious with the interpretation of the 1 mg dexamethasone suppression test for Cushing's screening, aside from oral estrogen use?
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Endocrinology · Johns Hopkins Department Of Endocrinology Diabetes And Metabolism
Answered on
We usually do not measure CBG level during the 1-mg DST. If a woman is on oral estrogen, one may wait for the total cortisol level; if abnormal, repeat the test with free cortisol measurement or measure free cortisol proactively to avoid delays in test interpretation. A nice paper from the Mayo Clin...
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