How does a strong family history of breast cancer influence your decision between RAI and thyroidectomy for definitive treatment of hyperthyroidism, in light of emerging observational data suggesting a possible association between RAI and increased breast cancer risk?

There is an increased risk for solid tumors, especially breast cancer, following radioactive iodine (relative risk from 0.45-2.55). This data is strongest for those treated for thyroid cancer as opposed to Graves disease, as it is dose dependent, but studies do support an increased risk for breast c...