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How does metaplastic thymoma histology impact your decision regarding adjuvant radiation?

E.g. would it prompt you to offer adjuvant RT in Masaoka IIA? Does the histology have a different prognosis?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Mayo Clinic
Answered on

This is a good question. I honestly have never seen this histology, and I help write the UpToDate thymoma section and am a thymoma enthusiast (meaning I like to read about it/treat it, not to have it). Thymomas really run the spectrum of aggressiveness, and the approach to them in the adjuvant setting does change a bit depending on the histology. I read "metaplastic"... sounds not good. Then read, "It's a biphasic mass of spindle cells and epithelial cells" which also sounds worrisome, but then ...

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