How does omalizumab play a role in the armamentarium of atopic dermatitis?

There are various reports (>30 citations) in the literature documenting Xolair efficacy in atopic dermatitis. The study designs include randomized placebo-controlled trials, retrospective case series, and case studies.

A review of the literature published in 2019 by Holm & Thomsen, PMID 30717578 provides a summary of outcomes and a meta-analysis in 2016 by Wang et al., PMID 27543070 identified potential treatment responder profile.

Overall there are mixed findings regarding efficacy. While there are studies documenting clinical benefit and resolution of eczema, a small number of studies showed no improvement of disease with Xolair. There are mixed findings for improvements in clinical parameters and SCORAD/IGA changes, despite some findings s...