How does the presence of MMR deficiency affect your decision to treat with 3 versus 6 months of adjuvant chemotherapy in high risk stage III colon cancer?

For stage III dMMR colon cancer patients, oxaliplatin-based adjuvant chemotherapy should be offered as standard of care based on meta-analysis and fluoropyrimidine-only adjuvant chemotherapy is not beneficial (Jin and Sinicrope, PMID 33467526. Cohen et al., PMID 33356421).

For high risk stage III co...