How does the presence of myositis alter your interpretation of cardiac enzymes when evaluating acute chest pain?

Troponin T and CK-MB are not reliable for cardiac issues in myositis as regenerating muscles produce these enzymes. This is especially true if the patient has an active disease with weakness and CK elevation.

Troponin I is not much affected by muscle enzymes and should be used as a parameter to eval...

TPN-I is 95% specific for true cardiac involvement in inflammatory myopathies.

SKELETAL myositis causes TPN-T elevation, which is not due to cardiac injury. Also, CK-MB loses specificity in myositis. TPN-T is elevated in 69% of patients with skeletal myositis.