How does topiramate fit into your treatment paradigm for prevention of episodic migraine?

1.) Topiramate has excellent evidence for efficacy, including better than the evidence for beta blockers, amitriptyline, and venlafaxine, which this guideline recommended as first-line. I have a hard time saying these meds should be recommended as first-line over topiramate due to the reliance on ol...

I use topiramate as a first-line preventative medication. I would consider topiramate, TCAs, beta-blockers, and venlafaxine to be the first line. I may choose a medication based on comorbidities such as mood disorder, insomnia, obesity, hypertension, etc. All of these can cause side effects and I do...

I agree with Dr. @Dr. First Last, I would add to his list of suggestions zonisamide, which I find lighter than topiramate in terms of cognitive suppression, with overall better tolerability. I would also add candesartan, 4-16 mg, to the list of migraine prophylactic medications. As others have menti...

I respectfully disagree with dear Dr. @Dr. First Last. In my practice, I have seen topiramate has been relatively effective with 80% reduction of migraines frequency and intensity when it reaches to 2 months of duration at 25 to 50 mg BID with minimal side effects in younger patients.

As everyone kn...

I prescribe Topiramate for migraine prevention in patients who:

• Have dual purposes, such as weight-loss considerations.
• Do not have contraindications like pregnancy, a history of kidney stones, or closed-angle glaucoma.
• Need to try other medications like CGRP inhibitors due to insurance constraints...

I agree with Dr. @Dr. First Last. None of my patients could afford a CGRP as a first-line treatment. The side effects of topiramate (paresthesias, cognition changes, and weight loss) occur early and resolve completely. Longer-term effects (kidney stones) are an issue only if years of treatment have ...

As far as I am concerned, topiramate has no place anymore in migraine prevention, especially because of poor tolerability with the potential of affecting cognitive functioning. In the relatively low dose of 50 -100 mg daily, it was compared with erenumab, 70 or 140 mg subcutaneously monthly, in a ra...

Thank you all for this interesting discussion. Most of my patients really want to work with a natural treatment first. My own experience is that with improvements in sleep, exercise, and diet along with 400 magnesium oxide, about 50% of patients have their headaches reduced to the point where nothin...