How does your approach to low-risk gestational trophoblastic neoplasia differ for patients whose hCG levels plateau following initial single agent systemic therapy vs those who have a good initial response and then plateau?

Topics: Gynecologic Cancers • Medical Oncology • NCI-CCC Tumor Board Question • University of Florida • NCI-CCC Gynecologic Tumor Board Question • Gestational Trophoblastic Disease

Answer from: Medical Oncologist at Academic Institution

For patients with low risk GTN whose hCG values plateau over a two-week interval, concerns arise about chemoresistance. Unfortunately, there is no consensus or clear guideline in terms of determining chemoresistance and when to switch therapy. I don't approach the two clinical scenarios presented he...

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