How effective do you find MAO-B inhibitors for the treatment of Parkinson's disease?  

In the earlier stages of PD, MAO inhibitors have a perceptible effect, and in the early stages of treatment of PD, they are used alone or more effectively in combination with L-DOPA.

In a new patient with early mild symptoms, especially unilateral (Stage I), MAO-B inhibitors can be used. If you look at the Data from the TEMPO Study and Adagio study, Rasagiline 1 mg daily can have mild symptomatic benefits. In some patients, it may be the only drug they need for the next 2-5 year...