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How have you approached monitoring for severe side effects of ketamine treatments in the treatment of depression?

Severe side effects such as: impaired hepatobiliary function potentially leading to cholangitis, bladder dysfunction or hemorrhagic cystitis, and diabetes insipidus. Do you routinely monitor LFTs and UAs?
1 Answer
Mednet MemberInvited Expert
Psychiatry · Seattle Neuropsychiatric Treatment Center
Answered on

So... I'd say I'd never seen such severe side effects in my patients, and partially this is because ketamine infusions, done according to the expert guidelines (we use APA expert guidelines), are quite safe. We absolutely get a medical workup on every single patient, and we repeat the same workup on a yearly basis, if someone continues infusions this long. The continuation past a year's mark is uncommon, partially because of the price, partially because most of the time, the positive effect of ketamine wears off with repeated treatments, and because people find other (better or more durable?) treatments.

The medical workup includes a complete metabolic panel, urine tox screen, complete blood cell count, TSH, and EKG. I'll admit we just trie...

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