How has the introduction of lumasiran affected the need for combined liver and kidney transplantation in patients with ESKD related to primary hyperoxaluria type 1?

A kidney transplant alone with lumasiran pre and post-transplant to maintain lowered serum oxalate levels and prevent the recurrence of oxalate stones is potentially a viable option for simultaneous liver-kidney transplantation.

To date, there is only one small case series published of this approach ...

I agree with Dr. @Dr. First Last. There is increasing experience in treating PH1 patients with Lumasiran and proceeding with a kidney-alone transplant instead of a kidney plus liver. At this time, every case must be viewed individually with the risks and benefits of both approaches carefully conside...