How have the 2026 CHEST clinical practice guidelines for biologic management in severe asthma affected your management of these patients given the conditional strength of recommendations and very low certainty supporting evidence using the GRADE approach?

I applaud the panel for their objective, comprehensive analysis of these questions. The recommendations that they made for the 7 clinically relevant questions are sensible and actionable. The challenge, even using GRADE-based recommendations, is that (appropriately based upon existing evidence) the ...