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Please select the option that best describes you:
Topics:
Internal Medicine
•
Rheumatology
•
Systemic lupus erythematosus
•
Complement system
How have you utilized commercial lab "SLE Monitoring Profiles" that include C3a and C4a components?
What are the limitations, usefulness, and caveats of this testing?
Related Questions
How do you interpret high C1q binding assay with otherwise normal C1q, C3, C4, CH50 in a patient with recurrent urticaria with positive ANA at high titer 1:1280, negative dsDNA, RNP, SM, normal CBC, CMP, UA, and UPCR.
What is your approach to practical monitoring of lupus disease activity in clinical practice?
What is the clinical significance of a low titer RNP, negative Sm, but Sm/RNP that is very high titer?
How would you approach management of a young male patient with discoid lupus who has had minimal response to hydroxychloroquine (and subtherapeutic whole blood levels) who continues to use tobacco products?
How would you approach the management of a new SLE patient presenting with lupus podocytopathy with FSGS and severe proteinuria (Pr/Cr 18) without immune complex deposition?
How would you approach a young patient with bilateral lower extremity muscle weakness and positive anti-Smith, dsDNA, RNP, Raynaud’s, and pericardial effusion but normal muscle enzymes?
Would you increase the hydroxychloroquine dose to more than 5 mg/kg/day in a compliant patient with active non-organ threatening lupus (skin+joints) if serum hydroxychloroquine is not at goal until you reach an acceptable concentration?
What is your approach to dosing and duration of rituximab for refractory lupus nephritis not responsive to cyclophosphamide or mycophenolate?
Do you recommend avoidance of vaginal estrogen in patients with SLE?
What is your approach to the diagnosis and management of optic chiasmitis in systemic lupus erythematosus?