How, if at all, should a positive thrombophilia result influence the duration of anticoagulation following a first VTE provoked by a transient risk factor?

Following a first transiently provoked VTE, which thrombophilia findings, if already known, would generally favor extended anticoagulation?

• None — thrombophilia status alone would not change anticoagulation duration
• APS only
• APS or high-risk inherited thrombophilia (e.g., antithrombin deficiency, homozygous FVL, compound FVL/PTM), but not isolated heterozygous FVL/PTM
• Any confirmed thrombophilia, including isolated heterozygous FVL/PTM
• Other