Most patients will received adjuvant chemotherapy for 3-4 cycles.  Adjuvant chemo typically begins 4-12 weeks after surgery.  Therefore, the initiation of adjuvant sequential Osimertinib would typically occur 3 weeks after the last cycle of chemotherapy.  

This is also a tough question, particularly if a patient comes for a new consultation with you outside of the window that was allowed for the trial. On the trial, if a patient did not get adjuvant chemotherapy, he or she had to be randomized by 10 weeks after surgery, and if the patient did get adju...

While the trial allowed 12 weeks if no adjuvant therapy and up to 24 weeks for patients who received adjuvant therapy, I would stick with that.