How long after intrathecal chemotherapy do you typically wait before giving whole brain radiation?
Do you modify your dose/fractionation depending on the amount of prior intrathecal therapy?
Answer from: Radiation Oncologist at Academic Institution
This depends on the diagnosis and the reason for pursuing whole brain radiotherapy after intrathecal chemotherapy. For example, if this is a primary CNS lymphoma case with a patient who has progressed despite intrathecal chemotherapy I would likely proceed with whole brain radiotherapy relatively so...
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