How long do you expect gastrointestinal side effects of leflunomide to persist after stopping treatment?

Leflunomide (LEF) has a long half-lasting of about 15 days. So, when dealing with advise events such as gastrointestinal toxicity, these may persist up to several weeks following discontinuation of the drug.

Simply discontinuing LEF will prove to be effective in the majority of patients with adverse...

Agree. However, it is difficult to adhere to a several-day regimen of cholestyramine for obvious reasons. In the original phase 3 RCTs, a single dose of cholestyramine was administered for intolerable/severe AEs, and these resolved very quickly, as a single dose reduces blood levels of LEF by approx...