How long do you give neoadjuvant therapy in resectable/borderline resectable pancreatic cancer, when you are considering chemoradiotherapy as part of your neoadjuvant strategy?

Topics: Gastrointestinal Cancers • Medical Oncology • Liver and Pancreas Tumors • NCI-CCC Tumor Board Question • University of Wisconsin

I have seen anywhere from 4-6 months utilized. Is there any data to guide your strategy?

Answer from: Medical Oncologist at Academic Institution

I would aim for at least 6 cycles. A recent large study from Mayo Clinic evaluated 194 patients with borderline resectable or locally advanced pancreatic adenocarcinoma treated with neoadjuvant chemotherapy followed by concurrent chemoradiation therapy. 94% of patients had an R0 resectio...

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