How long do you give neoadjuvant therapy in resectable/borderline resectable pancreatic cancer, when you are considering chemoradiotherapy as part of your neoadjuvant strategy?

I would aim for at least 6 cycles. A recent large study from Mayo Clinic evaluated 194 patients with borderline resectable or locally advanced pancreatic adenocarcinoma treated with neoadjuvant chemotherapy followed by concurrent chemoradiation therapy. 94% of patients had an R0 resection.

Only 3 fac...