How long would you continue atezolizumab/bevacizumab in a patient with HCC who is having a prolonged response with stable disease?

Similar to how this was done in the phase 3 trial of atezolizumab/bevacizumab (vs sorafenib), I continue until progression or intolerance. Finn et al., PMID 32402160

This is a perfectly reasonable approach that @Dr. First Last outlined. However, I'm not sure that there is any specific reason to privilege the approach from this study above any other approach (such as discontinuation of immunotherapy after two years of therapy, as is commonly done in other disease...

I agree with @Dr. First Last. With stable disease, treatment should continue until progression or intolerance. For those patients with a complete response (5-10%), there has been some data to suggest that stopping therapy is possible; however, recurrence can range from 14-40% (Lim et al., PMID 39998...