How many statins do you try before considering alternative therapies like PCSK9 inhibitors or inclisiran to lower LDL levels?

How many statins do you try in a patient reporting statin intolerance before considering PCSK9 inhibitors or inclisiran?

• I try 1 to 2 statins at maximally tolerated doses before escalating to non-statin therapies
• I try 3 to 4 different statins before considering non-statin therapies
• I reduce the statin to the maximally tolerated dose and add ezetimibe before considering PCSK9 inhibitors or inclisiran
• I move directly to non-statin therapies after a single statin intolerance if the patient is high risk
• Other