How might the introduction of brensocatib as a treatment option impact the use of other anti- inflammatory or antibiotic therapies currently employed in bronchiectasis management?  

I would hesitate to add brensocatib in someone on asthma biologics. In the ASPEN trial for brensocatib, patients with a "primary" diagnosis of asthma were excluded from the study. I would not have any problem with adding brensocatib if they were on chronic azithromycin (around 20% of the patients re...