Topics:
Rheumatology • Myositis
How much weight would you place on a low titer Ku antibody in a patient with mild CPK elevation but no weakness on exam and no other features of CTD overlap syndrome?
Would you consider EMG, muscle biopsy, repeat myositis panel? Would you consider starting immunosuppression?
Answer from: at Academic Institution
Not much as we know autoantibodies can be false positive especially at low titre. I do not treat patients with just autoantibody without any clinical feature. If this patient has anti-Ku antibody with elevated CK, I would just monitor the patient regularly for development of new clinical symptoms/si...
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