How often do you monitor CD-19 counts and immunoglobulin levels in MS patients on B-cell depletion therapy?

How do you approach low IgG levels on these medications?

Answer from: at Academic Institution

This is a very timely question and one that is largely unresolved. There is currently no consensus on whether or how frequently gamma globulin levels should be monitored. Similarly, there is no consensus regarding the frequency of CD19 monitoring.Monitoring CD19 counts after rituximab therapy for pa...

Comments

at UPMC
Will you check CD20 too?If the patient doesn't hav...

at Riverside Medical Group
Dr. @John Lincoln, this was extremely helpful. App...

at UTHealth
Dr. @Weizhen Wang, this is a provocative question....

at UTHealth
Thank you for the kind comment, Dr. @Ahmed Abdelka...

at UPMC
This is an excellent reason for these patients (NM...

at Portsmouth Naval Medical Center
Very helpful information, Dr. @Lincoln. Thanks.

at Rancho Los Amigos National Rehabilitation Center
Since the beginning of the pandemic, I have been c...

Answer from: at Academic Institution

The biggest concern is not when/whether you should monitor for CD 19 cell counts but why we don’t. In more ways than one, this question or doubt about the use of anti-CD 20 therapies began in 2017 after the approval of the first drug for multiple sclerosis in this class. First of all, the...

Related Questions