How should dose homogeneity across bone be handled in pediatric patients?

The radiation-associated bone damage can be affected by many factors, including total radiation dose, fractionation schedule, treatment volume, age of the child, symmetry of the delivered dose over vertebrae, developmental status of the irradiated growth plates, treatments such as chemotherapy or su...

To minimize the likelihood of asymmetrical growth, when is it of sufficient concern to necessitate altering planning objectives?
What ages are relevant for this consideration?

The SIOPE Radiotherapy working group recently published consensus recommendations for management of vertebral radiotherapy dos...