How should I interpret a Gleason 7 prostate cancer (4+3 or 3+4) with tertiary grade 5?
Would you treat this as high risk?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on
The scoring system adopted by 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma specified that in a prostate biopsy, the two numbers should be the primary pattern and the highest grade (not the second most common type as was done before). For example, tumors with Gleason score 3 + 4 and a tertiary pattern 5 would be recorded as Gleason score 3 + 5 = 8 in the biopsy report to avoid undertreating as these patients have worse outcomes then 3+4.
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