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How should verrucous carcinomas of the head and neck be managed?

Should lymph nodes ever be targeted? If bone invasion or erosion is present, and surgery is not feasible, is radiation appropriate, and to what dose?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Henry Ford Health System
Answered on

This is a very interesting question. Most of the data and information regarding the management of this entity is obtained from case series and small retrospective series. There are 3 main issues to consider with regards to the use of radiation therapy for verrucous carcinomas of the head and neck.

  1. Concern for de-differentiation/ anaplastic transformation to invasive squamous cell carcinoma
  2. Comparison between surgery and radiation therapy
  3. Management of the neck

Verrucous carcinoma (VC) was initia...

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