How would manage a patient with stage III anal cancer and history of Child–Pugh B liver cirrhosis with platelets count of less than 100,000?

This is a tough situation and there is no great evidence for it.

Stage III Anal cancer (would assume this is referring to anal canal squamous cell carcinoma) is potentially curable and the guideline recommends concurrent chemoradiation. Would consider to be relatively aggressive if possible given the curative intent treatment, if the patient is a reasonable candidate for this approach.

The most common chemo regimen to give is 5Fu/Mitomycin. We know that 5Fu will possibly be safe to give but th...