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How would you approach a laryngeal adenoid cystic carcinoma in a patient seeking larynx preservation?

4 Answers

Mednet Member

Radiation Oncology · UTMB

This is a rare case scenario (laryngeal ACC) in a rare cancer (ACC) of an uncommon group of malignancies (primary salivary gland malignancies) for which direct evidence is sparse. I would, therefore, approach with some general principles and a generous pinch of salt in this scenario. The initial tre...

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Radiation Oncology · Emory University

I have treated 2 patients definitively with primary laryngeal ACC who declined laryngectomy. Both had excellent local control to 70 Gy but both progressed with distant metastatic disease to the lung (and liver in 1 patient).

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Radiation Oncology · University of Florida

Partial laryngectomy

2/21/2024

Definitive RT

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Radiation Oncology · REAC/TS(NNSA DOE)

Pre-op chemotherapy/immunotherapy, follow with partial laryngectomy if possible, or if no surgery, treat with neutron therapy — treat with post op XRT (if partial laryngectomy is possible.) And, for all the above options, consider long term post therapy chemotherapy/immunotherapy.