How would you approach a patient with incidentally noted infrarenal periaortitis with positive C-ANCA, normal inflammatory markers and no systemic symptoms?

Topics: Rheumatology • Vasculitis

MPO/PR3, P-ANCA negative. IgG4 normal.

Answer from: at Community Practice

Based on data we and others have published over the past 20 years, the specificity of testing for ANCA depends on testing for antibodies to the specific antigens proteinase 3 (PR3) and myeloperoxidase (MPO) by ELISA or other newer methods. Immunofluorescence (IF) testing alone for ANCA is not accept...

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