How would you approach a patient with metastatic alveolar rhabdomyosarcoma with progression on first-line therapy?
1 Answer
Mednet MemberInvited Expert
Pediatric Hematology/Oncology · Connecticut Children's Medcl Center
Answered on
Progression while on therapy in the setting of initially metastatic rhabdomyosarcoma is a very unfortunate situation for which I would not consider there to be curative options.
The first consideration I would give in this setting is to assess if there are any available clinical trials. If no clinical trials options are accessible, then there are a few chemotherapy regimens that could be used with the hope of response.
In this setting, I would consider vinorelbine/cyclophosphamide/temsirolimus, Cyclophosphamide/topotecan, oral cyclophosphamide, and vinorelbine, or vincristine/irinotecan (if not already given).
The following reference could be helpful:
See table 1.
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