How would you approach a patient with metastatic colon cancer and BRCA2 mutation in next generation sequencing?

We detect more mutations as more patients get next generation sequencing during their colorectal cancer treatment. The BRCA mutation is one of them.

BRCA mutations are typically associated with breast, ovarian, pancreas, and prostate cancers. The relationship between BRCA mutations and colorectal cancer is uncertain. There is a meta-analysis included 14 studies which reported a statistically significant increase of the risk of colorectal cancer in BRCA mutation carrier (HR 1.24, 95% CI 1.01-1.51). Further analysis revealed that only BRCA 1 mutation is associated with increased risk of colorectal cancer (HR 1.49, 95% CI 1.19-1.85) (Oh et al., J Nat Cancer Inst 2018).

Based on our current understanding of the role of BRCA mutations in cancer tr...