How would you approach a patient with newly diagnosed lupus/lupus nephritis receiving cyclophosphamide (euro lupus protocol) with active hemolysis not responding to steroids or IVIG?

Addition of rituximab on top of CYC? Increase dose of the CYC? Belimumab? Other thoughts? Consider other differentials?

Answer from: at Community Practice

Most importantly, the cause of the hemolysis must be figured out. I'd consider the following and order the following tests for each. The treatment varies depending on the cause: Autoimmune hemolytic anemia (AIHA) from SLE: assess the peripheral smear looking for spherocytes and measure direct Coo...

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at UTMB Health
As Dr. @Thomas points out, hemolytic anemia in a p...

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How would you approach a patient with newly diagnosed lupus/lupus nephritis receiving cyclophosphamide (euro lupus protocol) with active hemolysis not responding to steroids or IVIG?

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