How would you approach a patient with plasmablastic lymphoma of the nasal cavity s/p excisional biopsy to positive margins who is not a candidate for systemic therapy?

Plasmablastic lymphoma is a particularly aggressive non-Hodgkin lymphoma. It commonly arises in the H&N region, often in patients who are immunosuppressed for one reason or another. Most patients present with advanced disease.

For patients with stage I-II disease, a combined modality therapy approach...