Systemic treatment is the standard approach for metastatic anal squamous cell cancer. Carboplatin plus paclitaxel or 5FU plus cisplatin are reasonable choices. Recently, the InterAACT trial (Rao et al. JCO 2020) involving 91 patients comparing carboplatin/paclitaxel to 5FU/cisplatin showed similar O...

I completely agree with @Nguyen H. Tran's response. Careful selection would be the key for pursuing metastatectomy in the stage IV setting. For this case I would only add upfront evaluation by colorectal surgery to assess the primary site and ensure a patent lumen, otherwise upfront diversion may be...