How would you approach a postmenopausal patient with HR-,HER2+ breast cancer who has oligometastatic disease, and is s/p complete resection of brain met with no other evidence of systemic disease?

For local control, I would do stereotactic radiosurgery to the resection cavity. This is in line with NCCN guidelines and randomized trials, such as N107C, that show excellent local control with similar survival and better QOL compared to whole brain radiation.

I would also recheck markers on the bra...