How would you approach a supraclavicular high grade monophonic synovial sarcoma?

When I see a patient who has had a partial excision of a soft tissue sarcoma, I approach further therapy as I would a new diagnosis. Our preference, in a location where wide surgical resection is often difficult, is to use preoperative RT followed by surgical resection, and that is what I would do i...

Preop RT and surgery.

I agree with the above, preoperative RT followed by surgery. Postop in this location can also be challenging, so I would favor preop.

I agree with the above. If the lesion is amenable to a curative resection, I'd offer preoperative radiotherapy, followed by resection.

If the lesion is borderline resectable or potentially unresectable, then there may be a role for neoadjuvant chemotherapy to try to downstage the lesion to facilita...